Patients with symptomatic knee osteoarthritis (OA) are more sensitive to various pain stimuli, new data confirm, but the good news is that joint replacement can normalize the pain response. The study, by Thomas Graven-Nielsen and colleagues, published in Arthritis & Rheumatism, p

Objective. Musculoskeletal US is being increasingly used for the assessment of synovitis, although questions remain about its reliability. One potential factor affecting reliability is the lack of consensus of image acquisition methods such as using different joint positions. Thi

Objectives. The p38 mitogen-activated protein kinase (MAPK) signal transduction pathway is involved in a variety of inflammatory responses, including cytokine generation, cell differentiation proliferation and apoptosis. Here, we examined the effects of systemic p38 MAPK inhibiti

Effective osteoarthritis (OA) therapies would delay the need for total joint replacement (TJR). Recently, a committee of researchers attempted to develop a threshold for virtual TJR to be used as a standardized outcome for OA trials; their failure highlights challenges that compl

Mesenchymal stem cells (MSCs) suspended in hyaluronic acid can retard cartilage damage progression when injected into the joints of animals with surgically-induced symptoms of osteoarthritis (OA), but the disease course in such models is more rapid than in people with OA. Now, Ke

Publishing in Arthritis Research & Therapy, Rik Lories and colleagues at the Katholieke Universiteit Leuven, Belgium, provide new insight into the role of the FRZB gene?encoding a Wnt signaling pathway antagonist that has been linked to osteoarthritis (OA)?in joint homeostasis.Tr

Objective. The aim of this study was to use quantitative sensory testing (QST) to explore the range and prevalence of somatosensory abnormalities demonstrated by patients with advanced knee OA. Methods. One hundred and seven knee OA patients and 50 age- and sex-matched healthy p

Researchers at the Rothman Institute at Jefferson have shown that local anesthesia delivered through a catheter in the joint, intraarticularly, may be more beneficial than traditional opioids such as morphine and Oxycontin for pain management following total knee replacement surg

A new study has demonstrated that a procedure wherein healthy cartilage is transplanted to fix an area of damaged cartilage (osteoarticular cartilage transplantation or OATS procedure) is superior to the standard of care for repairing cartilage defects...

A 12-month randomized double blind clinical trial in 60 patients with active erosive hand osteoarthritis compared TNF blockade using adalimumab (40 mg fortnightly subcutaneous administration) with placebo. Whereas no benefit could be attributed to adalimumab overall, the drug sig